High systemic availability of core-crosslinked polymeric micelles after subcutaneous administration.

@article{Hu2016HighSA,
  title={High systemic availability of core-crosslinked polymeric micelles after subcutaneous administration.},
  author={Qizhi Hu and Jai Prakash and Cristianne J.F. Rijcken and Wim E. Hennink and Gert Storm},
  journal={International journal of pharmaceutics},
  year={2016},
  volume={514 1},
  pages={
          112-120
        }
}
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A new method for the determination of total and released docetaxel from docetaxel‐entrapped core‐crosslinked polymeric micelles (CriPec®) by LC–MS/MS and its clinical application in plasma and tissues in patients with various tumours

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TLDR
It was found that after a single i.v. injection, the formulations with the slower drug release Kinetics maintained longer duration of therapeutic activity than those with relatively faster drug release kinetics, resulting in better joint protection.
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