High syndecan-1 expression in breast carcinoma is related to an aggressive phenotype and to poorer prognosis.

@article{Barbareschi2003HighSE,
  title={High syndecan-1 expression in breast carcinoma is related to an aggressive phenotype and to poorer prognosis.},
  author={Mattia Barbareschi and Patrick Maisonneuve and Daniela Aldovini and Maria Giulia Cangi and Lorenza Pecciarini and Francesco Angelo Mauri and Silvio Marco Veronese and Orazio Caffo and Antonio Lucenti and Paolo Dalla Palma and Enzo Galligioni and Claudio Doglioni},
  journal={Cancer},
  year={2003},
  volume={98 3},
  pages={474-83}
}
BACKGROUND Syndecan-1 is a transmembrane heparan sulphate proteoglycan that is involved in cell-cell adhesion, organization of cell-matrix adhesion, and regulation of growth factor signaling. METHODS Specimens from 254 consecutive breast carcinoma (BC) cases (110 N0, 144 N1/2) with long-term follow-up (median, 95 months) were immunostained for syndecan-1, estrogen receptor (ER), progesterone receptor (PgR), and p53; in 154 cases, c-erbB-2 status was known. Syndecan-1 mRNA and protein… CONTINUE READING

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