High susceptibility of MDR and XDR Gram-negative pathogens to biphenyl-diacetylene-based difluoromethyl-allo-threonyl-hydroxamate LpxC inhibitors.

@article{Titcat2016HighSO,
  title={High susceptibility of MDR and XDR Gram-negative pathogens to biphenyl-diacetylene-based difluoromethyl-allo-threonyl-hydroxamate LpxC inhibitors.},
  author={M. Tit{\'e}cat and Xiaofei Liang and C. Lee and A. Charlet and D. Hocquet and T. Lambert and J. Pag{\'e}s and R. Courcol and F. Sebbane and E. Toone and P. Zhou and N. Lema{\^i}tre},
  journal={The Journal of antimicrobial chemotherapy},
  year={2016},
  volume={71 10},
  pages={
          2874-82
        }
}
OBJECTIVES Inhibitors of uridine diphosphate-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase (LpxC, which catalyses the first, irreversible step in lipid A biosynthesis) are a promising new class of antibiotics against Gram-negative bacteria. The objectives of the present study were to: (i) compare the antibiotic activities of three LpxC inhibitors (LPC-058, LPC-011 and LPC-087) and the reference inhibitor CHIR-090 against Gram-negative bacilli (including MDR and XDR isolates); and… Expand
14 Citations
Treatment of human challenge and MDR strains of Neisseria gonorrhoeae with LpxC inhibitors
  • 2
  • PDF
Design, Synthesis, and Properties of a Potent Inhibitor of Pseudomonas aeruginosa Deacetylase LpxC.
  • 17
3D-QSAR, Molecular Docking and Molecular Dynamics Simulation of Pseudomonas aeruginosa LpxC Inhibitors
  • Ke Zuo, L. Liang, +5 authors J. Hu
  • Chemistry, Medicine
  • International journal of molecular sciences
  • 2017
  • 7
  • PDF
Sulfonamide-based non-alkyne LpxC inhibitors as Gram-negative antibacterial agents.
  • 12
Dual Role of gnaA in Antibiotic Resistance and Virulence in Acinetobacter baumannii
  • 4
  • PDF
The Mla pathway is critical for Pseudomonas aeruginosa resistance to outer membrane permeabilization and host innate immune clearance
  • 14
  • PDF
...
1
2
...

References

SHOWING 1-10 OF 33 REFERENCES
Structural basis of the promiscuous inhibitor susceptibility of Escherichia coli LpxC.
  • 20
  • PDF
The Challenge of Efflux-Mediated Antibiotic Resistance in Gram-Negative Bacteria
  • 643
...
1
2
3
4
...