High susceptibility of MDR and XDR Gram-negative pathogens to biphenyl-diacetylene-based difluoromethyl-allo-threonyl-hydroxamate LpxC inhibitors.

@article{Titcat2016HighSO,
  title={High susceptibility of MDR and XDR Gram-negative pathogens to biphenyl-diacetylene-based difluoromethyl-allo-threonyl-hydroxamate LpxC inhibitors.},
  author={M. Tit{\'e}cat and Xiaofei Liang and C. Lee and A. Charlet and D. Hocquet and T. Lambert and J. Pag{\'e}s and R. Courcol and F. Sebbane and E. Toone and P. Zhou and N. Lema{\^i}tre},
  journal={The Journal of antimicrobial chemotherapy},
  year={2016},
  volume={71 10},
  pages={
          2874-82
        }
}
  • M. Titécat, Xiaofei Liang, +9 authors N. Lemaître
  • Published 2016
  • Biology, Medicine
  • The Journal of antimicrobial chemotherapy
  • OBJECTIVES Inhibitors of uridine diphosphate-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase (LpxC, which catalyses the first, irreversible step in lipid A biosynthesis) are a promising new class of antibiotics against Gram-negative bacteria. The objectives of the present study were to: (i) compare the antibiotic activities of three LpxC inhibitors (LPC-058, LPC-011 and LPC-087) and the reference inhibitor CHIR-090 against Gram-negative bacilli (including MDR and XDR isolates); and… CONTINUE READING
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