High susceptibility of MDR and XDR Gram-negative pathogens to biphenyl-diacetylene-based difluoromethyl-allo-threonyl-hydroxamate LpxC inhibitors.

@article{Titcat2016HighSO,
  title={High susceptibility of MDR and XDR Gram-negative pathogens to biphenyl-diacetylene-based difluoromethyl-allo-threonyl-hydroxamate LpxC inhibitors.},
  author={Marie Tit{\'e}cat and Xiaofei Liang and Chul-Jin Lee and Audrey Charlet and Didier Hocquet and Thierry Lambert and Jean-Marie Pag{\'e}s and Ren{\'e} J. Courcol and Florent Sebbane and Eric J. Toone and Pei Zhou and Nadine Lema{\^i}tre},
  journal={The Journal of antimicrobial chemotherapy},
  year={2016},
  volume={71 10},
  pages={2874-82}
}
OBJECTIVES Inhibitors of uridine diphosphate-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase (LpxC, which catalyses the first, irreversible step in lipid A biosynthesis) are a promising new class of antibiotics against Gram-negative bacteria. The objectives of the present study were to: (i) compare the antibiotic activities of three LpxC… CONTINUE READING