High-speed force spectroscopy unfolds titin at the velocity of molecular dynamics simulations.

@article{Rico2013HighspeedFS,
  title={High-speed force spectroscopy unfolds titin at the velocity of molecular dynamics simulations.},
  author={Felix Rico and Laura Gonz{\'a}lez and Ignacio Casuso and Manel Puig-Vidal and Simon Scheuring},
  journal={Science},
  year={2013},
  volume={342 6159},
  pages={
          741-3
        }
}
The mechanical unfolding of the muscle protein titin by atomic force microscopy was a landmark in our understanding of single-biomolecule mechanics. Molecular dynamics simulations offered atomic-level descriptions of the forced unfolding. However, experiment and simulation could not be directly compared because they differed in pulling velocity by orders of magnitude. We have developed high-speed force spectroscopy to unfold titin at velocities reached by simulation (~4 millimeters per second… CONTINUE READING
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