High specificity of a phosphate transport protein determined by hydrogen bonds

@article{Luecke1990HighSO,
  title={High specificity of a phosphate transport protein determined by hydrogen bonds},
  author={Hartmut Luecke and Florante A. Quiocho},
  journal={Nature},
  year={1990},
  volume={347},
  pages={402-406}
}
TRANSPORT of the essential nutrient phosphorus—primarily in the form of orthophosphate—into cells and organelles is highly specific. This is exemplified by the uptake of phosphate or its close analogue arsenate by bacterial cells by way of a high affinity active transport system dependent on a phosphate-binding protein; this system is unable to recognize other inorganic oxyanions and is, moreover, distinct from the one for sulphate transport1,2. The phosphate-binding protein is a member of a… CONTINUE READING
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