High serum leptin is associated with attenuated coronary vasoreactivity.

  title={High serum leptin is associated with attenuated coronary vasoreactivity.},
  author={J. R. Sundell and Risto K. Huupponen and Olli T. Raitakari and P. Nuutila and Juhani Knuuti},
  journal={Obesity research},
  volume={11 6},
OBJECTIVE Hyperleptinemia, a hallmark of obesity, appears to be a risk factor for coronary artery disease. However, although leptin is a vasoactive hormone, no studies addressing leptin's effect on coronary perfusion have been performed. We examined the association between circulating leptin concentration and coronary vasoreactivity in young obese and nonobese males. RESEARCH METHODS AND PROCEDURES Myocardial blood flow was quantitated in 10 obese men (age 31 +/- 7 years, BMI 34 +/- 2 kg/m(2… CONTINUE READING
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