High serum concentration of YKL-40 is associated with short survival in patients with acute myeloid leukemia.

@article{Bergmann2005HighSC,
  title={High serum concentration of YKL-40 is associated with short survival in patients with acute myeloid leukemia.},
  author={Olav Jonas Bergmann and Julia Sidenius Johansen and T W Klausen and Anne K{\ae}rsgaard Mylin and J\orgen Sch\oler Kristensen and Eigil Kjeldsen and Hans Erik Johnsen},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2005},
  volume={11 24 Pt 1},
  pages={8644-52}
}
PURPOSE YKL-40 is secreted by cancer cells, macrophages, and neutrophils. It may be a growth or differentiation factor, play a role in angiogenesis, or protect against apoptosis. High serum YKL-40 is associated with poor prognosis in solid carcinomas. The aim was to examine serum YKL-40 in patients with acute myeloid leukemia (AML). EXPERIMENTAL DESIGN YKL-40 was measured by ELISA in serum from 77 patients recently diagnosed with AML before and during the first month of chemotherapy… CONTINUE READING