High serum antibody levels to Porphyromonas gingivalis predict myocardial infarction

  title={High serum antibody levels to Porphyromonas gingivalis predict myocardial infarction},
  author={Pirkko J Pussinen and Georg Alfthan and Jaakko Tuomilehto and Sirkka Asikainen and Pekka Jousilahti},
  journal={European Journal of Preventive Cardiology},
  pages={408 - 411}
Background An association between coronary heart disease (CHD) and clinically diagnosed periodontitis has been found in several epidemiological studies. However, seroepidemiologic evidence based on prospective data on this association is totally lacking. Design The aim of the study was to investigate serum antibodies to major periodontal pathogens for their prediction of myocardial infarction (MI) in men free of CHD at baseline. Methods Cases and controls were ascertained from a random… 

Serum Antibody Levels to Actinobacillus actinomycetemcomitans Predict the Risk for Coronary Heart Disease

High-serum antibody levels to major periodontal pathogens are associated with subclinical, prevalent, and future incidence of CHD.

Antibodies to Periodontal Pathogens and Stroke Risk

Serological evidence is provided that an infection caused by major periodontal pathogens is associated with future stroke in a case–control study in Finland.

Prediagnostic plasma antibody levels to periodontopathic bacteria and risk of coronary heart disease.

The possible role of periodontopathic bacteria as a risk factor for CHD incidence was suggested by the results of this study by the elevated antibody level to these bacteria with the increased risk of CHD.

Association between periodontal pathogens and risk of nonfatal myocardial infarction.

The presence ofperiodontal pathogens, specifically Tf or Pi, and an increase in total burden of periodontal pathogenic species were both associated with increased odds of having MI, but further studies are needed to better assess any causal relationship.

Immunologic burden links periodontitis to acute coronary syndrome.

Antibodies to periodontal pathogens and coronary artery calcification in type 1 diabetic and nondiabetic subjects.

Elevated levels of serum IgG to P. gingivalis and A. actinomycetemcomitans are associated with coronary artery atherosclerosis, particularly in patients with type 1 diabetes, and may reflect a direct role for periodontal infection or a role for the host response to infection in coronary Atherosclerosis.

Serum antibodies to periodontal pathogens and markers of systemic inflammation.

High serum titre to P. gingivalis and the presence of periodontal disease are independently related to high CRP levels.

Porphyromonas gingivalis (Pg) a possible link between impaired oral health and acute myocardial infarction.




Antibodies to Periodontal Pathogens Are Associated With Coronary Heart Disease

The association of coronary heart disease (CHD) and serology of periodontitis in a random sample of men and serum IgG-antibodies to Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis suggests that periodontal infection or response of the host against the infection may play a role in the pathogenesis of CHD.

Serum antibodies to Bacteroides gingivalis in periodontitis: a longitudinal study.

Antibody titres reduced by half 1 year following scaling and root planing were observed in patients presumably infected with B. gingivalis, suggesting that the procedure effectively reduced the immune challenge.

Multiserotype Enzyme-Linked Immunosorbent Assay as a Diagnostic Aid for Periodontitis in Large-Scale Studies

The serotype mixture ELISA is suitable for measuring antibodies against periodontal pathogens in large epidemiological studies in order to evaluate the role of periodontitis as a risk factor for other diseases.

Identification of periodontal pathogens in atheromatous plaques.

periodontal pathogens are present in atherosclerotic plaques where, like other infectious microorganisms such as C. pneumoniae, they may play a role in the development and progression of atherosclerosis leading to coronary vascular disease and other clinical sequelae.

Porphyromonas gingivalis Infection Accelerates the Progression of Atherosclerosis in a Heterozygous Apolipoprotein E–Deficient Murine Model

Evidence is provided that long-term systemic challenge with Porphyromonas gingivalis, an oral pathogen, can accelerate atherogenic plaque progression.

Plasma lipid and blood glucose levels in patients with destructive periodontal disease.

The results indicate that hyperlipaemia and pre-diabetes may be associated with periodontal disease in systemically healthy subjects, but these data do not allow us to decide, whether periodental disease causes an increase in hyperlip aemia and in a prediabetic state or whether periodontAL disease and cardiovascular disease share hyperlipidaemia and the predi diabetic state as common risk factors.

Relationship of Periodontal Disease to Carotid Artery Intima-Media Wall Thickness: The Atherosclerosis Risk in Communities (ARIC) Study

Results provide the first indication that periodontitis may play a role in the pathogenesis of atheroma formation, as well as in cardiovascular events, in patients aged 52 to 75 years.

Periodontal Disease and Risk of Fatal Coronary Heart and Cerebrovascular Diseases

These data indicate that poor dental health is associated with an increased risk of fatal CHD, and Adjusted for age, sex, diabetes status, serum total cholesterol, smoking, hypertensive status, and province, this association is found.

Dental disease and risk of coronary heart disease and mortality.

Dental disease is associated with an increased risk of coronary heart disease, particularly in young men, and may be a more general indicator of personal hygiene and possibly health care practices.

Epidemiologic risk factors for periodontal attachment loss among adults in the United States.

Findings support earlier findings regarding the central role of cigarette smoking in the etiology of periodontal loss of attachment, a role due in large part to the substantial relationship between smoking and severeperiodontal disease.