High serum antibody levels to Porphyromonas gingivalis predict myocardial infarction

@article{Pussinen2004HighSA,
  title={High serum antibody levels to Porphyromonas gingivalis predict myocardial infarction},
  author={Pirkko J Pussinen and Georg Alfthan and Jaakko Tuomilehto and Sirkka Asikainen and Pekka Jousilahti},
  journal={European Journal of Preventive Cardiology},
  year={2004},
  volume={11},
  pages={408 - 411}
}
Background An association between coronary heart disease (CHD) and clinically diagnosed periodontitis has been found in several epidemiological studies. However, seroepidemiologic evidence based on prospective data on this association is totally lacking. Design The aim of the study was to investigate serum antibodies to major periodontal pathogens for their prediction of myocardial infarction (MI) in men free of CHD at baseline. Methods Cases and controls were ascertained from a random… 

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High-serum antibody levels to major periodontal pathogens are associated with subclinical, prevalent, and future incidence of CHD.

Antibodies to Periodontal Pathogens and Stroke Risk

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Prediagnostic plasma antibody levels to periodontopathic bacteria and risk of coronary heart disease.

The possible role of periodontopathic bacteria as a risk factor for CHD incidence was suggested by the results of this study by the elevated antibody level to these bacteria with the increased risk of CHD.

Association between periodontal pathogens and risk of nonfatal myocardial infarction.

The presence ofperiodontal pathogens, specifically Tf or Pi, and an increase in total burden of periodontal pathogenic species were both associated with increased odds of having MI, but further studies are needed to better assess any causal relationship.

Immunologic burden links periodontitis to acute coronary syndrome.

Antibodies to periodontal pathogens and coronary artery calcification in type 1 diabetic and nondiabetic subjects.

Elevated levels of serum IgG to P. gingivalis and A. actinomycetemcomitans are associated with coronary artery atherosclerosis, particularly in patients with type 1 diabetes, and may reflect a direct role for periodontal infection or a role for the host response to infection in coronary Atherosclerosis.

Serum antibodies to periodontal pathogens and markers of systemic inflammation.

High serum titre to P. gingivalis and the presence of periodontal disease are independently related to high CRP levels.

Porphyromonas gingivalis (Pg) a possible link between impaired oral health and acute myocardial infarction.

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