High seroprevalence of Borna virus infection in schizophrenic patients, family members and mental health workers in Taiwan

  title={High seroprevalence of Borna virus infection in schizophrenic patients, family members and mental health workers in Taiwan},
  author={C.-H. Chen and Y-L Chiu and F C Wei and F J Koong and H-C Liu and C K Shaw and Hai-Gwo Hwu and Kwang-jen Hsiao},
  journal={Molecular Psychiatry},
Borna disease virus (BDV), a negative-strand RNA virus, has been reported to be associated with severe psychiatric disorders. The association is mainly based on the findings that patients with schizophrenia and depression have a higher seroprevalence rate of BDV-specific antibodies than controls. In addition, psychiatric patients were also found to have a higher detection rate of BDV transcripts in their blood than controls. By using an improved Western blot analysis, we first demonstrated that… 
Detection of Borna disease virus RNA from peripheral blood cells in schizophrenic patients and mental health workers
The data support the finding that bdv infection might be a contributory factor to the pathogenesis of schizophrenia in the chinese population.
Borna disease virus infection in psychiatric patients: are we on the right track?
  • M. Schwemmle
  • Medicine, Psychology
    The Lancet. Infectious diseases
  • 2001
Immunological and PCR Analyses for Borna Disease Virus in Psychiatric Patients and Blood Donors in Japan
The usefulness of the proliferative T-cell response and that certain individuals are infected with BDV or a BDV-related virus are suggested.
Human Borna Disease Virus Infection
Since most of the RT-PCR products or virus isolates from brain tissue are identical in sequence to laboratory strains, one might be tempted to speculate that laboratory contaminations occurred in almost all cases of positive BDV results from human samples.
Borna Disease Virus and Psychiatric Disorders: Can Viruses Influence Psychiatric Disorders?
1.1 Psychiatric disorders and infectious diseases Psychiatric disorders are a wide group of diseases with a heterogeneous aetiology (genetic predisposition, environmental factors, exposure to stress,
Borna disease virus and psychiatry
Role of Infection, Autoimmunity, Atopic Disorders, and the Immune System in Schizophrenia: Evidence from Epidemiological and Genetic Studies.
Since there is also an increased risk of immune-related diseases after the diagnosis with schizophrenia and in family members of individuals with schizophrenia, parts of the association could also be due to heritable factors.
Autoimmune diseases and infections as risk factors for schizophrenia
Autoimmune diseases and infections should be considered in the treatment of individuals with schizophrenia symptoms, and further research is needed of the immune system's possible contributing pathogenic factors in the etiology of schizophrenia.
Borna Disease Virus and Human Disease
  • K. Carbone
  • Medicine, Biology
    Clinical Microbiology Reviews
  • 2001
The biology of Borna disease virus (BDV) strongly supports the likelihood of human infection with BDV or a variant of BDV, and clinical studies seeking causal associations between BDV infection and specific diseases must ensure the proper identification of the BDV infected subjects by using a validated, highly sensitive, and highly specific assay.
Borna disease virus: a mystery as an emerging zoonotic pathogen.
The role of BDV in human neuro-psychiatric disorders is questionable and, therefore, reports describing the presence of other BDV-markers, i.e.BDV-RNA or BDV -antigen, in peripheral blood leukocytes or brain tissue of neuro-Psychiatric patients are highly controversial.


Lack of association of Borna disease virus and human T-cell leukemia virus type 1 infections with psychiatric disorders among Japanese patients
There is a lack of association between BDV and HTLV-1 infections with psychiatric disorders among Japanese patients, and this is the first isolated human retrovirus that causes adult T-cell leukemia with neurological symptoms.
Positive and Negative Syndromes, and Borna Disease Virus Infection in Schizophrenia
It is possible that BDV infection with induction of BDV p24 antibodies may be associated with negative syndromes in schizophrenic patients.
Detection of Borna disease virus (BDV) antibodies and BDV RNA in psychiatric patients: evidence for high sequence conservation of human blood-derived BDV RNA
Serological and molecular epidemiological studies on psychiatric patients and healthy individuals from the area of Homburg, Germany show that BDV p40 and p24 sequences derived from human PBMCs exhibited both a high degree of inter- and intrapatient conservation and a close genetic relationship to animal-derived BDV sequences.
Borna disease virus and schizophrenia
Failure to detect Borna disease virus infection in peripheral blood leukocytes from humans with psychiatric disorders.
Prior work with BDV sequences in the assay environment, together with the exquisite sensitivity of RT-PCR, may account for the sporadic appearance of false positive evidence that BDV-specific RNA is present in human blood cells.
First isolates of infectious human Borna disease virus from patients with mood disorders.
Isolation of BDV from patients with major mood disorders at a time of acute depression strengthens the possibility that BDV infection is one of the environmental factors that contributes to recurrent depressive illnesses in man.
Detection of serum antibodies to Borna disease virus in patients with psychiatric disorders.
Antibodies to the virus were demonstrated in 16 of the patients but none of the normal volunteers, and patients with the positive serum samples were characterized by having histories of affective disorders, particularly of a cyclic nature.