High seroprevalence of Borna virus infection in schizophrenic patients, family members and mental health workers in Taiwan

@article{Chen1999HighSO,
  title={High seroprevalence of Borna virus infection in schizophrenic patients, family members and mental health workers in Taiwan},
  author={C.-H. Chen and Y-L Chiu and F. Wei and F. Koong and H.-C. Liu and C. Shaw and H. Hwu and K. Hsiao},
  journal={Molecular Psychiatry},
  year={1999},
  volume={4},
  pages={33-38}
}
Borna disease virus (BDV), a negative-strand RNA virus, has been reported to be associated with severe psychiatric disorders. The association is mainly based on the findings that patients with schizophrenia and depression have a higher seroprevalence rate of BDV-specific antibodies than controls. In addition, psychiatric patients were also found to have a higher detection rate of BDV transcripts in their blood than controls. By using an improved Western blot analysis, we first demonstrated that… Expand
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Detection of Borna disease virus RNA from peripheral blood cells in schizophrenic patients and mental health workers
TLDR
The data support the finding that bdv infection might be a contributory factor to the pathogenesis of schizophrenia in the chinese population. Expand
Borna disease virus infection in psychiatric patients: are we on the right track?
TLDR
This view is challenged by the observation that human BDV-reactive antibodies are of low avidity and might therefore represent cross-reacting antibodies, which remains to be shown whether these antibodies are indeed induced by BDV or by related antigens of unknown identity. Expand
Primary psychosis and Borna disease virus infection in Lithuania: a case control study
TLDR
A significantly higher prevalence of CIC, indicating a chronic BDV infection, in patients with treated primary psychosis than in blood donor controls is found, thus supporting similar global trends for other mental disorders. Expand
Immunological and PCR Analyses for Borna Disease Virus in Psychiatric Patients and Blood Donors in Japan
TLDR
The usefulness of the proliferative T-cell response and that certain individuals are infected with BDV or a BDV-related virus are suggested. Expand
Health care professionals at risk of infection with Borna disease virus – evidence from a large hospital in China (Chongqing)
TLDR
BDV circulates unnoticed in hospital settings in China, putting medical staff at risk and warranting clarification of infection modes and introduction of prevention measures. Expand
Evidence for Borna disease virus infection in neuropsychiatric patients in three western China provinces
  • L. Zhang, M.-M. Xu, +11 authors P. Xie
  • Medicine
  • European Journal of Clinical Microbiology & Infectious Diseases
  • 2013
TLDR
It is demonstrated that BDV infection also exists in humans from three western China provinces, and the involvement of the contribution of BDV in the aetiology of Chinese patients with some neuropsychiatric disorders, including viral encephalitis, schizophrenia, CFS, multiple sclerosis and Parkinson’s disease is suggested. Expand
Borna disease virus and infection in humans.
TLDR
Serological and molecular data support the possibility of human infection with Borna disease virus and support the absence of a link between BDV infection and psychiatric disorders as well as excluding it as a human pathogen. Expand
Human Borna Disease Virus Infection
TLDR
Since most of the RT-PCR products or virus isolates from brain tissue are identical in sequence to laboratory strains, one might be tempted to speculate that laboratory contaminations occurred in almost all cases of positive BDV results from human samples. Expand
Borna Disease Virus and Psychiatric Disorders: Can Viruses Influence Psychiatric Disorders?
1.1 Psychiatric disorders and infectious diseases Psychiatric disorders are a wide group of diseases with a heterogeneous aetiology (genetic predisposition, environmental factors, exposure to stress,… Expand
Borna disease virus and the evidence for human pathogenicity: a systematic review.
TLDR
There is evidence that humans are exposed to the Borna Disease virus, and agreed gold standard tests and evidence for test specificity are lacking, but further epidemiological studies are required to establish whether there are associations with disease. Expand
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References

SHOWING 1-10 OF 35 REFERENCES
Clinical investigation of the relationship between Borna disease virus (BDV) infection and schizophrenia in 67 patients in Japan
TLDR
It is possible that, at least, Borna disease virus infection in schizophrenic patients may not be a nosocomial (hospital‐acquired) infection, although the route of BDV infection in humans remains unidentified. Expand
Lack of association of Borna disease virus and human T-cell leukemia virus type 1 infections with psychiatric disorders among Japanese patients
TLDR
There is a lack of association between BDV and HTLV-1 infections with psychiatric disorders among Japanese patients, and this is the first isolated human retrovirus that causes adult T-cell leukemia with neurological symptoms. Expand
Positive and Negative Syndromes, and Borna Disease Virus Infection in Schizophrenia
TLDR
It is possible that BDV infection with induction of BDV p24 antibodies may be associated with negative syndromes in schizophrenic patients. Expand
Detection of Borna disease virus (BDV) antibodies and BDV RNA in psychiatric patients: evidence for high sequence conservation of human blood-derived BDV RNA
TLDR
Serological and molecular epidemiological studies on psychiatric patients and healthy individuals from the area of Homburg, Germany show that BDV p40 and p24 sequences derived from human PBMCs exhibited both a high degree of inter- and intrapatient conservation and a close genetic relationship to animal-derived BDV sequences. Expand
Borna disease virus and schizophrenia
TLDR
The Western blot assay is superior to IFA assays in BDV serology studies, detection of antibodies to more than one BDV protein is a useful working criterion for seropositivity, and there is tentative evidence for a schizophrenia-control difference in the prevalence of anti-BDV antibodies. Expand
Detection of Borna disease virus-reactive antibodies from patients with affective disorders by western immunoblot technique.
Borna disease (BD) virus is a partially characterized neurotropic agent with a predilection for neurons and astrocytes in the limbic system and cerebrum of infected hosts. Although it usually causes… Expand
Failure to detect Borna disease virus infection in peripheral blood leukocytes from humans with psychiatric disorders.
TLDR
Prior work with BDV sequences in the assay environment, together with the exquisite sensitivity of RT-PCR, may account for the sporadic appearance of false positive evidence that BDV-specific RNA is present in human blood cells. Expand
First isolates of infectious human Borna disease virus from patients with mood disorders.
TLDR
Isolation of BDV from patients with major mood disorders at a time of acute depression strengthens the possibility that BDV infection is one of the environmental factors that contributes to recurrent depressive illnesses in man. Expand
Detection of serum antibodies to Borna disease virus in patients with psychiatric disorders.
TLDR
Antibodies to the virus were demonstrated in 16 of the patients but none of the normal volunteers, and patients with the positive serum samples were characterized by having histories of affective disorders, particularly of a cyclic nature. Expand
Human infections with Borna disease virus: Seroprevalence in patients with chronic diseases and healthy individuals
TLDR
A latent infection with BDV in humans leading to low antigen expression in healthy subjects and frequent reactivation events in chronically ill patients is suggested. Expand
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