High sensitivity of transgenic mice expressing soluble TNFR1 fusion protein to mycobacterial infections: synergistic action of TNF and IFN-gamma in the differentiation of protective granulomas.

@article{Garca1997HighSO,
  title={High sensitivity of transgenic mice expressing soluble TNFR1 fusion protein to mycobacterial infections: synergistic action of TNF and IFN-gamma in the differentiation of protective granulomas.},
  author={Isbel Garc{\'i}a and Yasunari Miyazaki and Gilles Marchal and Werner Lesslauer and Pierre Vassalli},
  journal={European journal of immunology},
  year={1997},
  volume={27 12},
  pages={3182-90}
}
To investigate the role of tumor necrosis factor (TNF) in protective immune responses to Mycobacterium tuberculosis and M. bovis Bacillus Calmette Guérin (BCG), we have used transgenic mice unable to use TNF because of the expression of high amounts of a soluble TNF receptor (R) type I (sTNFR1) fusion protein, and studied resistance of these mice to… CONTINUE READING