High sensitivity of Nrf2 knockout mice to acetaminophen hepatotoxicity associated with decreased expression of ARE-regulated drug metabolizing enzymes and antioxidant genes.

@article{Enomoto2001HighSO,
  title={High sensitivity of Nrf2 knockout mice to acetaminophen hepatotoxicity associated with decreased expression of ARE-regulated drug metabolizing enzymes and antioxidant genes.},
  author={Akiko Enomoto and Ken Itoh and Emi Nagayoshi and Jun-ichi Haruta and Takeshi Kimura and Tracy O'Connor and Tsuyoshi Harada and Masayuki Yamamoto},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2001},
  volume={59 1},
  pages={169-77}
}
Nrf2, which belongs to the basic leucine zipper (bZip) transcription factor family, has been implicated as a key molecule involved in antioxidant-responsive element (ARE)-mediated gene expression. In order to examine the role of Nrf2 in protection against xenobiotic toxicity, the sensitivity of nrf2 knockout mice to acetaminophen (N-acetyl-4-aminophenol (APAP)) was analyzed. The saturation of detoxification pathways after high levels of exposure to APAP is known to induce hepatotoxicity. Two… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 242 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 42 references

Acetaminopheninduced hepatotoxicity. InToxicology of the Liver(G

  • S. D. Cohen, D. J. Hoivik, E. A. Khairallah
  • 1998
1 Excerpt

Similar Papers

Loading similar papers…