High sensitivity and specificity of elevated cerebrospinal fluid kappa free light chains in suspected multiple sclerosis

@article{HassanSmith2014HighSA,
  title={High sensitivity and specificity of elevated cerebrospinal fluid kappa free light chains in suspected multiple sclerosis},
  author={Ghaniah Hassan-Smith and Lindsay Durant and Aikaterini Tsentemeidou and Lakhvir Kaur Assi and S. John Curnow},
  journal={Journal of Neuroimmunology},
  year={2014},
  volume={276},
  pages={175-179}
}
Cerebrospinal fluid (CSF) analysis is routinely used in the diagnostic work-up of multiple sclerosis (MS), by detecting CSF-specific oligoclonal bands (OCB). More recently, several studies have reported CSF free light chains (FLC) as an alternative. We show that absolute CSF κFLC concentrations were highly sensitive - more than OCB testing - and specific for clinically isolated syndrome, relapsing remitting and primary progressive MS. Measurement of κFLC alone was sufficient. Our results… CONTINUE READING

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