High-sensitivity C-reactive protein as a serum predictor of nonalcoholic fatty liver disease based on the Akaike Information Criterion scoring system in the general Japanese population

@article{Kogiso2009HighsensitivityCP,
  title={High-sensitivity C-reactive protein as a serum predictor of nonalcoholic fatty liver disease based on the Akaike Information Criterion scoring system in the general Japanese population},
  author={Tomomi Kogiso and Yuriko Moriyoshi and Satoru Shimizu and Hikaru Nagahara and Keiko Shiratori},
  journal={Journal of Gastroenterology},
  year={2009},
  volume={44},
  pages={313-321}
}
BackgroundHigh-sensitivity C-reactive protein (hs-CRP) has been developed and used as a marker to predict coronary vascular diseases in metabolic syndrome (MS). We investigated whether serum hs-CRP concentration was associated with nonalcoholic fatty liver disease (NAFLD) based on the Akaike Information Criterion (AIC) scoring system, using patients from the human dry dock program.MethodsFrom 2004 to 2005, 1254 subjects visited our human dry dock annual checkup program. We excluded from this… Expand
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References

SHOWING 1-10 OF 42 REFERENCES
C-reactive protein level as an independent risk factor of metabolic syndrome in the Korean population. CRP as risk factor of metabolic syndrome.
TLDR
It is demonstrated that CRP is a strong associating factor of MS in Korean population and recommended further evaluation of CRP levels in the other Asian ethnic groups to establish biological plausibility as the risk factor for MS in all ethnic groups. Expand
Relationship of serum high sensitivity C-reactive protein to metabolic syndrome and microvascular complications in type 2 diabetes.
TLDR
Serum hsCRP level has a significant correlation with MS and might be used as the future criteria of MS and among microvascular complications, only diabetic nephropathy is associated with the serum hs CRP level. Expand
Association Between Elevated Liver Enzymes and C-Reactive Protein: Possible Hepatic Contribution to Systemic Inflammation in the Metabolic Syndrome
TLDR
Elevations of liver enzymes are associated with higher CRP concentrations and Hepatic inflammation secondary to liver steatosis is a potential contributor to the low-grade inflammation associated with the metabolic syndrome. Expand
Fasting insulin and uric acid levels but not indices of iron metabolism are independent predictors of non-alcoholic fatty liver disease. A case-control study.
  • A. Lonardo, P. Loria, +8 authors N. Carulli
  • Medicine
  • Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
  • 2002
TLDR
Fasting insulin and serum uric acid levels indicating insulin resistance, but not indices of iron overload, are independent predictors of non-alcoholic fatty liver disease. Expand
Central obesity as a major determinant of increased high-sensitivity C-reactive protein in metabolic syndrome
TLDR
It is found that central obesity and high blood pressure are the most important determinants of the low-grade chronic inflammation present in metabolic syndrome. Expand
Insulin resistance and ferritin as major determinants of nonalcoholic fatty liver disease in apparently healthy obese patients
TLDR
These two factors were significantly associated with nonalcoholic fatty liver disease in obese patients, as both hyperinsulinemia induced by insulin resistance and iron overload represented by ferritin elevation might damage hepatocytes. Expand
Prevalence of and risk factors for nonalcoholic fatty liver disease: The Dionysos nutrition and liver study
TLDR
NAFLD is highly prevalent in the general population, is not associated with SLD, but is associated with many features of the metabolic syndrome. Expand
Liver markers and development of the metabolic syndrome: the insulin resistance atherosclerosis study.
TLDR
NAFLD markers ALT and the AST-to-ALT ratio predict metabolic syndrome independently of potential confounding variables, including directly measured Si and AIR. Expand
C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women.
TLDR
The addition of the measurement of C-reactive protein to screening based on lipid levels may provide an improved method of identifying persons at risk for cardiovascular events. Expand
Nonalcoholic Fatty Liver Disease Is Associated With Carotid Atherosclerosis: A Case–Control Study
TLDR
Patients with NAFLD show a cluster of risk factors of the metabolic syndrome and advanced carotid atherosclerosis, and its detection on abdominal ultrasound should alert to the existence of an increased cardiovascular risk. Expand
...
1
2
3
4
5
...