High-sensitivity BRAF mutation analysis: BRAF V600E is acquired early during tumor development but is heterogeneously distributed in a subset of papillary thyroid carcinomas.

@article{Biase2014HighsensitivityBM,
  title={High-sensitivity BRAF mutation analysis: BRAF V600E is acquired early during tumor development but is heterogeneously distributed in a subset of papillary thyroid carcinomas.},
  author={Dario de Biase and V. F. Cowling Cesari and Michela Visani and Gian Piero Casadei and Nadia Cremonini and Greta Gandolfi and Valentina Sancisi and Moira Ragazzi and Annalisa Pession and Alessia Ciarrocchi and G. Tallini},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2014},
  volume={99 8},
  pages={E1530-8}
}
CONTEXT The homogeneous distribution of BRAF V600E in papillary thyroid carcinoma (PTC) has been called into question by recent reports. These studies claim that BRAF V600E is heterogeneous and is limited to tumor cell subsets in the majority of PTCs. OBJECTIVE The objective of the study was to understand the allele distribution of BRAF V600E by evaluating the percentage of mutated neoplastic cells in a group of PTCs using two different highly sensitive analytical approaches: allele-specific… CONTINUE READING

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Next generation sequencing improves the accuracy of KRAS mutation analysis in endoscopic ultrasound fine needle aspiration pancreatic lesions

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