High salt primes a specific activation state of macrophages, M(Na)

  title={High salt primes a specific activation state of macrophages, M(Na)},
  author={Wu-Chang Zhang and Xiao-jun Zheng and Lin-Juan Du and Jian-yong Sun and Zhu-xia Shen and Chaoji Shi and Shuyang Sun and Zhiyuan Zhang and Xiao-qing Chen and Mu Qin and Xu Liu and Jun Tao and Lijun Jia and Heng-Yu Fan and Bin Zhou and Ying Yu and Hao Ying and Lijian Hui and Xiaolong Liu and Xianghua Yi and Xiaojing Liu and Lanjing Zhang and Sheng-Zhong Duan},
  booktitle={Cell Research},
High salt is positively associated with the risk of many diseases. However, little is known about the mechanisms. Here we showed that high salt increased proinflammatory molecules, while decreased anti-inflammatory and proendocytic molecules in both human and mouse macrophages. High salt also potentiated lipopolysaccharide-induced macrophage activation and suppressed interleukin 4-induced macrophage activation. High salt induced the proinflammatory aspects by activating p38/cFos and/or Erk1/2… CONTINUE READING
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