High salt intake reprioritizes osmolyte and energy metabolism for body fluid conservation.

  title={High salt intake reprioritizes osmolyte and energy metabolism for body fluid conservation.},
  author={Kento Kitada and Steffen Daub and Yahua Zhang and Janet D Klein and Daisuke Nakano and Tetyana V Pedchenko and Louise Lantier and Lauren M LaRocque and Adriana Marton and Patrick Neubert and Agnes Schroeder and Natalia Rakova and Jonathan Jantsch and Anna E. Dikalova and Sergey I. Dikalov and David G Harrison and Dominik N M{\"u}ller and Akira Nishiyama and Manfred Rauh and Raymond C Harris and Friedrich C. Luft and David H Wassermann and Jeff M Sands and Jens M. Titze},
  journal={The Journal of clinical investigation},
  volume={127 5},
Natriuretic regulation of extracellular fluid volume homeostasis includes suppression of the renin-angiotensin-aldosterone system, pressure natriuresis, and reduced renal nerve activity, actions that concomitantly increase urinary Na+ excretion and lead to increased urine volume. The resulting natriuresis-driven diuretic water loss is assumed to control the extracellular volume. Here, we have demonstrated that urine concentration, and therefore regulation of water conservation, is an important… CONTINUE READING


Publications citing this paper.
Showing 1-9 of 9 extracted citations

An Increasingly Complex Relationship Between Salt and Water.

American journal of kidney diseases : the official journal of the National Kidney Foundation • 2017
View 1 Excerpt

Salt and water: not so simple.

The Journal of clinical investigation • 2017
View 2 Excerpts


Publications referenced by this paper.
Showing 1-10 of 107 references

Urea and Ammonia Metabolism and the Control of Renal Nitrogen Excretion.

Clinical journal of the American Society of Nephrology : CJASN • 2015
View 1 Excerpt

ferential gene expression in the liver of the African lungfish , Protopterus annectens , after 6 months of aestivation in air or 1 day of arousal from 6 months of aestivation

CJ Ramnanan, DC McMullen, AG Groom, KB Storey
PLoS One • 2015

APC ( CDH 1 ) targets MgcRacGAP for destruction in the late M phase

M. Min, U. Mayor, C. Lindon
PLoS One • 2013

Similar Papers

Loading similar papers…