High risk of recurrent stroke after discontinuance of five to twelve years of transfusion therapy in patients with sickle cell disease.

@article{Wang1991HighRO,
  title={High risk of recurrent stroke after discontinuance of five to twelve years of transfusion therapy in patients with sickle cell disease.},
  author={Winfred C. Wang and Edward H. Kovnar and Ina L. D. Tonkin and Raymond K. Mulhern and James William Langston and Sara Williamson Day and Michael J. Schell and Judith A. Wilimas},
  journal={The Journal of pediatrics},
  year={1991},
  volume={118 3},
  pages={
          377-82
        }
}
Although long-term transfusion therapy is at least 90% effective in preventing recurrent strokes after an initial cerebrovascular accident in patients with sickle cell disease, it is unknown how long transfusion therapy should be continued. To address this question, we prospectively discontinued transfusions in 10 patients with sickle cell disease whose median duration of transfusion therapy after an initial stroke was 9 1/2 years (range 5 to 12 years). Before the transfusions were discontinued… CONTINUE READING
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