High risk of graft failure in patients with anti-HLA antibodies undergoing haploidentical stem-cell transplantation.

@article{Ciurea2009HighRO,
  title={High risk of graft failure in patients with anti-HLA antibodies undergoing haploidentical stem-cell transplantation.},
  author={Stefan O Ciurea and Marcos de Lima and Pedro Cano and Martin Korbling and Sergio Giralt and Elizabeth J Shpall and Xuemei Wang and Peter F. Thall and Richard E. Champlin and Marcelo H. Fernandez-Vi{\~n}a},
  journal={Transplantation},
  year={2009},
  volume={88 8},
  pages={1019-24}
}
BACKGROUND.: Although donor-specific anti-human leukocyte antigen (HLA) antibodies (DSA) have been implicated in graft rejection in solid organ transplantation, their role in hematopoietic stem-cell transplantation remains unclear. METHODS.: To address the hypothesis that the presence of DSA contributes to the development graft failure, we tested 24 consecutive patients for the presence of anti-HLA antibodies determined by a sensitive and specific solid-phase/single-antigen assay. The study… CONTINUE READING