High-risk human papillomavirus type 18 E7 caused p27 elevation and cytoplasmic localization.

@article{Yan2010HighriskHP,
  title={High-risk human papillomavirus type 18 E7 caused p27 elevation and cytoplasmic localization.},
  author={Xiaofei Yan and Walayat Shah and Li Jing and Hongwei Chen and Yi-Li Wang},
  journal={Cancer biology & therapy},
  year={2010},
  volume={9 9},
  pages={
          728-35
        }
}
The tumor suppressor p27(Kip1) is an inhibitor of cyclin/cyclin-dependent kinase (CDK) complexes and plays a crucial role in cell cycle regulation. Nevertheless, p27 function in the tumorigenesis of the uterine cervix has been poorly defined. Some phenomenon hints that HPV E7 protein can enhance p27 expression, which is contradictory to HPV E7's property of increasing cell proliferation rate. So, in the present study, we have examined the effect of E7 on p27 expression. Though the levels of p27… CONTINUE READING
BETA

Topics from this paper.

Similar Papers

Loading similar papers…