High-risk human papillomavirus in nasopharyngeal carcinoma.

@article{Singhi2012HighriskHP,
  title={High-risk human papillomavirus in nasopharyngeal carcinoma.},
  author={Aatur D Singhi and Joseph Califano and William H Westra},
  journal={Head & neck},
  year={2012},
  volume={34 2},
  pages={
          213-8
        }
}
BACKGROUND Human papillomavirus (HPV), a cause of oropharyngeal carcinoma, has also been implicated as an etiologic agent in nasopharyngeal carcinomas. METHODS We performed p16 immunohistochemistry and in situ hybridization for Epstein-Barr virus (EBV) and HPV on 45 carcinomas of the nasopharynx. RESULTS Thirty-four (76%) carcinomas were EBV-positive/HPV-negative, 7 (16%) were EBV-negative/HPV-negative, and 4 (9%) were EBV-negative/HPV-positive. HPV was more likely to be detected in… CONTINUE READING
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