High-resolution two-dimensional gel electrophoresis analysis of atrial tissue proteome reveals down-regulation of fibulin-1 in atrial fibrillation.

@article{Garcia2011HighresolutionTG,
  title={High-resolution two-dimensional gel electrophoresis analysis of atrial tissue proteome reveals down-regulation of fibulin-1 in atrial fibrillation.},
  author={A. Garcia and S. Eiras and A. F. Pargui{\~n}a and J. Alonso and I. Rosa and A. Salgado-Somoza and Trinidad Yolanda Rico and E. Teijeira-Fern{\'a}ndez and J. Gonz{\'a}lez-Juanatey},
  journal={International journal of cardiology},
  year={2011},
  volume={150 3},
  pages={
          283-90
        }
}
BACKGROUND Atrial fibrillation (AF) is the most common cardiac arrhythmia found in clinical practice. We combined high-resolution two-dimensional gel electrophoresis (2-DE) and mass spectrometry (MS) to compare the atrial proteome of subjects with AF versus controls with sinus rhythm (SR). Our aim was to identify novel differentially regulated proteins that could be related to the development of the arrhythmia. METHODS Human atrial appendage tissue samples from patients undergoing heart… Expand
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