High-resolution two-dimensional gel electrophoresis analysis of atrial tissue proteome reveals down-regulation of fibulin-1 in atrial fibrillation.

  title={High-resolution two-dimensional gel electrophoresis analysis of atrial tissue proteome reveals down-regulation of fibulin-1 in atrial fibrillation.},
  author={A. Garcia and S. Eiras and A. F. Pargui{\~n}a and J. Alonso and I. Rosa and A. Salgado-Somoza and Trinidad Yolanda Rico and E. Teijeira-Fern{\'a}ndez and J. Gonz{\'a}lez-Juanatey},
  journal={International journal of cardiology},
  volume={150 3},
BACKGROUND Atrial fibrillation (AF) is the most common cardiac arrhythmia found in clinical practice. We combined high-resolution two-dimensional gel electrophoresis (2-DE) and mass spectrometry (MS) to compare the atrial proteome of subjects with AF versus controls with sinus rhythm (SR). Our aim was to identify novel differentially regulated proteins that could be related to the development of the arrhythmia. METHODS Human atrial appendage tissue samples from patients undergoing heart… Expand
22 Citations
Comparative proteomic analysis of atrial appendages from rheumatic heart disease patients with sinus rhythm and atrial fibrillation.
  • 12
High-Resolution Separation of Cardiovascular Proteomes: Two-Dimensional Electrophoresis and Liquid Chromatography
  • O. Drews
  • Biology, Medicine
  • Circulation. Cardiovascular genetics
  • 2012
  • 3
  • PDF
Cardiac protein changes in ischaemic and dilated cardiomyopathy: a proteomic study of human left ventricular tissue
  • 22
Getting to the Heart of the Matter.
  • H. Calkins
  • Medicine
  • Arrhythmia & electrophysiology review
  • 2017
Getting to the Heart of the Matter
  • 2


Combined metabolomic and proteomic analysis of human atrial fibrillation.
  • 165
  • Highly Influential
  • PDF
Matrix metalloproteinase-9 contributes to human atrial remodeling during atrial fibrillation.
  • 135
Alterations in contractile protein composition and function in human atrial dilatation and atrial fibrillation.
  • 51
Heat shock proteins as molecular targets for intervention in atrial fibrillation.
  • 59
  • PDF
Reprogramming of the Human Atrial Transcriptome in Permanent Atrial Fibrillation: Expression of a Ventricular-Like Genomic Signature
  • 162
  • PDF
Molecular Determinants of Altered Ca2+ Handling in Human Chronic Atrial Fibrillation
  • 238
Relationship of interleukin-6 and C-reactive protein to the prothrombotic state in chronic atrial fibrillation.
  • 253
Characterization of circulating human monocytes by proteomic analysis.
  • 13