High-resolution structures of variant Zif268-DNA complexes: implications for understanding zinc finger-DNA recognition.

@article{ElrodErickson1998HighresolutionSO,
  title={High-resolution structures of variant Zif268-DNA complexes: implications for understanding zinc finger-DNA recognition.},
  author={Monicia Elrod-Erickson and Timothy E. Benson and Carl O. Pabo},
  journal={Structure},
  year={1998},
  volume={6 4},
  pages={451-64}
}
BACKGROUND Zinc fingers of the Cys2-His2 class comprise one of the largest families of eukaryotic DNA-binding motifs and recognize a diverse set of DNA sequences. These proteins have a relatively simple modular structure and key base contacts are typically made by a few residues from each finger. These features make the zinc finger motif an attractive system for designing novel DNA-binding proteins and for exploring fundamental principles of protein-DNA recognition. RESULTS Here we report the… CONTINUE READING

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