High-resolution structure of a picornaviral internal cis-acting RNA replication element (cre).

  title={High-resolution structure of a picornaviral internal cis-acting RNA replication element (cre).},
  author={Varatharasa Thiviyanathan and Yan Yang and Kumaralal K Kaluarachchi and Rene Rijnbrand and David G. Gorenstein and Stanley M Lemon},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={101 34},
Picornaviruses constitute a medically important family of RNA viruses in which genome replication critically depends on a small RNA element, the cis-acting replication element (cre), that templates 3D(pol) polymerase-catalyzed uridylylation of the protein primer for RNA synthesis, VPg. We report the solution structure of the 33-nt cre of human rhinovirus 14 under solution conditions optimal for uridylylation in vitro. The cre adopts a stem-loop conformation with an extended duplex stem… CONTINUE READING

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