High-resolution profiling and discovery of planarian small RNAs.

  title={High-resolution profiling and discovery of planarian small RNAs.},
  author={Marc R. Friedl{\"a}nder and Catherine Adamidi and Ting Han and Svetlana Lebedeva and Thomas A. Isenbarger and Martin Hirst and Marco La Marra and Chad Nusbaum and William Y. L. Lee and James C Jenkin and Alejandro S{\'a}nchez Alvarado and John K. Kim and Nikolaus Rajewsky},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={106 28},
Freshwater planarian flatworms possess uncanny regenerative capacities mediated by abundant and collectively totipotent adult stem cells. Key functions of these cells during regeneration and tissue homeostasis have been shown to depend on PIWI, a molecule required for Piwi-interacting RNA (piRNA) expression in planarians. Nevertheless, the full complement… CONTINUE READING