High-resolution oligonucleotide array comparative genomic hybridization study and methylation status of the RPS14 gene in de novo myelodysplastic syndromes.

@article{Borze2010HighresolutionOA,
  title={High-resolution oligonucleotide array comparative genomic hybridization study and methylation status of the RPS14 gene in de novo myelodysplastic syndromes.},
  author={Ioana Borze and Eeva Juvonen and Shinsuke Ninomiya and Kowan Ja Jee and Erkki Elonen and Sakari Knuutila},
  journal={Cancer genetics and cytogenetics},
  year={2010},
  volume={197 2},
  pages={166-73}
}
In myelodysplastic syndromes (MDS), close to one half of patients do not have any visible karyotypic change. In order to study submicroscopic genomic alterations, we applied high-resolution array comparative genomic hybridization techniques (aCGH) in 37 patients with de novo MDS. Furthermore, we studied the methylation status of the RPS14 gene in 5q deletion (5q21.3q33.1) in 24 patients. In all, 21 of the 37 patients (57%) had copy number alterations. The most frequent copy number losses with… CONTINUE READING