High-resolution melting analysis (HRMA): more than just sequence variant screening.


Transition of the double-stranded DNA molecule to its two single strands, DNA denaturation or melting, has been used for many years to study DNA structure and composition. Recent technological advances have improved the potential of this technology, especially to detect variants in the DNA sequence. Sensitivity and specificity were increased significantly… (More)
DOI: 10.1002/humu.21019


6 Figures and Tables

Cite this paper

@article{Vossen2009HighresolutionMA, title={High-resolution melting analysis (HRMA): more than just sequence variant screening.}, author={Rolf H. A. M. Vossen and Emmelien Aten and A Hult Roos and Johan T den Dunnen}, journal={Human mutation}, year={2009}, volume={30 6}, pages={860-6} }