High-resolution mapping of heterochromatin redistribution in a Drosophila position-effect variegation model

@article{Vogel2008HighresolutionMO,
  title={High-resolution mapping of heterochromatin redistribution in a Drosophila position-effect variegation model},
  author={Maartje J Vogel and Ludo Pagie and Wendy Talhout and Marja Nieuwland and Ron M. Kerkhoven and Bas van Steensel},
  journal={Epigenetics & Chromatin},
  year={2008},
  volume={2},
  pages={1 - 1}
}
Position-effect variegation (PEV) is the stochastic transcriptional silencing of a gene positioned adjacent to heterochromatin. white-mottled X-chromosomal inversions in Drosophila are classic PEV models that show variegation of the eye color gene white due to its relocation next to pericentric heterochromatin. It has been suggested that in these models the spreading of heterochromatin across the rearrangement breakpoint causes the silencing of white. However, the extent of this spreading and… CONTINUE READING