High resolution mapping of expression QTLs in heterogeneous stock mice in multiple tissues.

@article{Huang2009HighRM,
  title={High resolution mapping of expression QTLs in heterogeneous stock mice in multiple tissues.},
  author={Guo-Jen Huang and Sagiv Shifman and William Valdar and Martina Johannesson and Binnaz Yalcin and Martin S. Taylor and Jennifer M. Taylor and Richard A Mott and Jonathan Flint},
  journal={Genome research},
  year={2009},
  volume={19 6},
  pages={1133-40}
}
A proportion of the genetic variants underlying complex phenotypes do so through their effects on gene expression, so an important challenge in complex trait analysis is to discover the genetic basis for the variation in transcript abundance. So far, the potential of mapping both quantitative trait loci (QTLs) and expression quantitative trait loci (eQTLs) in rodents has been limited by the low mapping resolution inherent in crosses between inbred strains. We provide a megabase resolution map… CONTINUE READING