High-resolution mapping of a 130-kb core region of the MYCN amplicon in neuroblastomas.


The MYCN proto-oncogene is amplified in 25% of neuroblastomas, and amplification is strongly correlated with advanced disease stage and with rapid tumor progression. We have generated a high-resolution restriction map of nearly 500 kb spanning the MYCN locus by subcloning yeast artificial chromosomes into cosmids. Cosmids plus additional amplified probes… (More)


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