High resolution mapping in the major histocompatibility complex region identifies multiple independent novel loci for psoriatic arthritis.

@article{Rahman2011HighRM,
  title={High resolution mapping in the major histocompatibility complex region identifies multiple independent novel loci for psoriatic arthritis.},
  author={Proton Rahman and Nicole M. Roslin and Fawnda J Pellett and Mathieu Lemire and Celia M. T. Greenwood and Joseph Beyene and Angela Pope and Lynette Peddle and Andrew D Paterson and Mohammed Rafiq Uddin and Dafna D Gladman},
  journal={Annals of the rheumatic diseases},
  year={2011},
  volume={70 4},
  pages={
          690-4
        }
}
OBJECTIVE Psoriatic arthritis (PsA) has a clear familial predisposition, the major histocompatibility complex (MHC) region being the strongest genetic locus. The study primary objective was to identify single nucleotide polymorphisms (SNPs) independent of known human leucocyte antigen (HLA) alleles within the MHC region that are associated with PsA using a high-density SNP map. METHOD In all, 914 samples were assessed, including 427 PsA cases from 2 well established PsA cohorts and 487… CONTINUE READING

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