High-resolution mapping identifies a commonly amplified 11q13.3 region containing multiple genes flanked by segmental duplications


DNA amplification of the 11q13 region is observed frequently in many carcinomas. Within the amplified region several candidate oncogenes have been mapped, including cyclin D1, TAOS1 and cortactin. Yet, it is unknown which gene(s) is/are responsible for the selective pressure enabling amplicon formation. This is probably due to the use of low-resolution… (More)
DOI: 10.1007/s00439-006-0299-6


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