High-resolution mapping defines the cooperative architecture of Polycomb response elements.

  title={High-resolution mapping defines the cooperative architecture of Polycomb response elements.},
  author={Guillermo A. Orsi and Sivakanthan Kasinathan and Kelly T Hughes and Sarah S. Saminadin-Peter and Steven Henikoff and K. Faraz Ahmad},
  journal={Genome research},
  volume={24 5},
Polycomb-mediated chromatin repression modulates gene expression during development in metazoans. Binding of multiple sequence-specific factors at discrete Polycomb response elements (PREs) is thought to recruit repressive complexes that spread across an extended chromatin domain. To dissect the structure of PREs, we applied high-resolution mapping of nonhistone chromatin proteins in native chromatin of Drosophila cells. Analysis of occupied sites reveal interactions between transcription… CONTINUE READING
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Highresolution mapping of transcription factor binding sites on native chromatin

  • S Kasinathan, GA Orsi, GE Zentner, K Ahmad, S. Henikoff
  • Nat Methods 11: 203–209.
  • 2014
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