High resolution manometry to detect transient lower oesophageal sphincter relaxations: diagnostic accuracy compared with perfused-sleeve manometry, and the definition of new detection criteria.

@article{Roman2011HighRM,
  title={High resolution manometry to detect transient lower oesophageal sphincter relaxations: diagnostic accuracy compared with perfused-sleeve manometry, and the definition of new detection criteria.},
  author={S Roman and Frank Zerbib and Kafia Belhocine and Stanislas Bruley des Varannes and F Mion},
  journal={Alimentary pharmacology & therapeutics},
  year={2011},
  volume={34 3},
  pages={384-93}
}
BACKGROUND Inhibition of transient lower oesophageal sphincter relaxations (tLESRs) has become one of the most relevant therapeutic objectives in patients with reflux symptoms resistant to proton pump inhibitors. tLESRs are currently detected by oesophageal perfused-sleeve manometry (PSM), but oesophageal high resolution manometry (HRM), which combines closely spaced pressure sensors and oesophageal pressure topography plots, may prove to be a better tool. AIM To evaluate the efficacy… CONTINUE READING

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Randomised clinical trial: effects of monotherapy with ADX10059, a mGluR5 inhibitor, on symptoms and reflux events in patients with gastro-oesophageal reflux disease

  • F Zerbib, S Bruley des Varannes, S Roman
  • Aliment Pharmacol Ther 2011;33:911-21
  • 2011
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