High resolution magic angle spinning NMR spectroscopy for metabolic assessment of cancer presence and Gleason score in human prostate needle biopsies

@article{Asten2008HighRM,
  title={High resolution magic angle spinning NMR spectroscopy for metabolic assessment of cancer presence and Gleason score in human prostate needle biopsies},
  author={Jack J. A. van Asten and Vincent M. J. I. Cuijpers and C. A. Hulsbergen-van de Kaa and Claudia Soede-Huijbregts and Johannes Alfred Witjes and Albert A. J. Verhofstad and Arend Heerschap},
  journal={Magnetic Resonance Materials in Physics, Biology and Medicine},
  year={2008},
  volume={21},
  pages={435-442}
}
Histopathology of prostate needle biopsies (PNBs) is an important part in the diagnosis, prognosis and treatment evaluation of prostate cancer. The determination of metabolite levels in the same biopsies may have additional clinical value. Here, we demonstrate the use of non-destructive high resolution magic angle spinning (HRMAS) proton NMR Spectroscopy for the assessment of metabolic profiles of prostate tissue in PNBs as commonly obtained in standard clinical practice. PNBs that were taken… CONTINUE READING

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