High-resolution genomic profiling of adenomas and carcinomas of the salivary glands reveals amplification, rearrangement, and fusion of HMGA2.

@article{Persson2009HighresolutionGP,
  title={High-resolution genomic profiling of adenomas and carcinomas of the salivary glands reveals amplification, rearrangement, and fusion of HMGA2.},
  author={Fredrik Persson and Ywonne Andr{\'e}n and Marta Winnes and Barbro Wedell and Anders Nordkvist and Gunhildur Gudnadottir and Rigmor Dahlenfors and Helene Sj{\"o}gren and Joachim Mark and G{\"o}ran Stenman},
  journal={Genes, chromosomes & cancer},
  year={2009},
  volume={48 1},
  pages={69-82}
}
Carcinoma ex pleomorphic adenoma (Ca-ex-PA) is an epithelial malignancy developing within a benign salivary gland pleomorphic adenoma (PA). Here we have used genome-wide, high-resolution array-CGH, and fluorescence in situ hybridization to identify genes amplified in double min chromosomes and homogeneously staining regions in PA and Ca-ex-PA and to identify additional genomic imbalances characteristic of these tumor types. Ten of the 16 tumors analyzed showed amplification/gain of a 30-kb… CONTINUE READING
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