High-resolution genomic mapping reveals consistent amplification of the fibroblast growth factor receptor substrate 2 gene in well-differentiated and dedifferentiated liposarcoma.

@article{Wang2011HighresolutionGM,
  title={High-resolution genomic mapping reveals consistent amplification of the fibroblast growth factor receptor substrate 2 gene in well-differentiated and dedifferentiated liposarcoma.},
  author={Xiaoke Wang and Yan W. Asmann and Michele R. Erickson-Johnson and Jennifer L Oliveira and Hongying Zhang and Rafael de Deus Moura and Alexander J Lazar and Dina Chelouche Lev and Katelynn Bill and Ricardo Vincent Lloyd and Michael J. Yaszemski and Avudaiappan Maran and Andr{\'e} Luiz Malavasi Longo de Oliveira},
  journal={Genes, chromosomes & cancer},
  year={2011},
  volume={50 11},
  pages={849-58}
}
Well-differentiated liposarcoma (WDLS) is one of the most common malignant mesenchymal tumors and dedifferentiated liposarcoma (DDLS) is a malignant tumor consisting of both WDLS and a transformed nonlipogenic sarcomatous component. Cytogenetically, WDLS is characterized by the presence of ring or giant rod chromosomes containing several amplified genes, including MDM2, TSPAN31, CDK4, and others mainly derived from chromosome bands 12q13-15. However, the 12q13-15 amplicon is large and… CONTINUE READING
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