High-resolution genome-wide in vivo footprinting of diverse transcription factors in human cells.

@article{Boyle2011HighresolutionGI,
  title={High-resolution genome-wide in vivo footprinting of diverse transcription factors in human cells.},
  author={Alan P. Boyle and Lingyun Song and Bum-kyu Lee and D. London and Damian Keefe and Ewan Birney and Vishwanath R. Iyer and Gregory E. Crawford and Terrence S. Furey},
  journal={Genome research},
  year={2011},
  volume={21 3},
  pages={456-64}
}
Regulation of gene transcription in diverse cell types is determined largely by varied sets of cis-elements where transcription factors bind. Here we demonstrate that data from a single high-throughput DNase I hypersensitivity assay can delineate hundreds of thousands of base-pair resolution in vivo footprints in human cells that precisely mark individual transcription factor-DNA interactions. These annotations provide a unique resource for the investigation of cis-regulatory elements. We find… CONTINUE READING
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