High-resolution genetic mapping with pooled sequencing

  title={High-resolution genetic mapping with pooled sequencing},
  author={Matthew D. Edwards and David Kenneth Gifford},
  booktitle={BMC Bioinformatics},
Modern genetics has been transformed by high-throughput sequencing. New experimental designs in model organisms involve analyzing many individuals, pooled and sequenced in groups for increased efficiency. However, the uncertainty from pooling and the challenge of noisy sequencing data demand advanced computational methods. We present MULTI POOL, a computational method for genetic mapping in model organism crosses that are analyzed by pooled genotyping. Unlike other methods for the analysis of… CONTINUE READING