High-resolution genetic mapping of the saccharin preference locus (Sac) and the putative sweet taste receptor (T1R1) gene (Gpr70) to mouse distal Chromosome 4

@article{Li2001HighresolutionGM,
  title={High-resolution genetic mapping of the saccharin preference locus (Sac) and the putative sweet taste receptor (T1R1) gene (Gpr70) to mouse distal Chromosome 4},
  author={Xia Li and Masashi Inoue and Danielle R Reed and Taufiqul Huque and Ralph B. Puchalski and Michael G Tordoff and Yuzo Ninomiya and Gary K. Beauchamp and Alexander A Bachmanov},
  journal={Mammalian Genome},
  year={2001},
  volume={12},
  pages={13-16}
}
The Sac (saccharin preference) locus affecting mouse behavioral and neural responsiveness to sweeteners has been mapped to distal Chr 4. A putative sweet taste receptor, T1R1, has been recently cloned, and the gene encoding it, Gpr70, has also been mapped to mouse distal Chr 4. To assess Gpr70 as a candidate gene for Sac, we compared the Gpr70 sequences of C57BL/6ByJ and 129P3/J mouse strains with different alleles of Sac. Using Gpr70 sequence variation between the C57BL/6ByJ and 129P3/J… CONTINUE READING
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