High-resolution genetic mapping of complex traits from a combined analysis of F2 and advanced intercross mice.

@article{Parker2014HighresolutionGM,
  title={High-resolution genetic mapping of complex traits from a combined analysis of F2 and advanced intercross mice.},
  author={Clarissa C Parker and Peter Carbonetto and Greta Sokoloff and Y. Jeanette Park and Mark Abney and Abraham A Palmer},
  journal={Genetics},
  year={2014},
  volume={198 1},
  pages={103-16}
}
Genetic influences on anxiety disorders are well documented; however, the specific genes underlying these disorders remain largely unknown. To identify quantitative trait loci (QTL) for conditioned fear and open field behavior, we used an F2 intercross (n = 490) and a 34th-generation advanced intercross line (AIL) (n = 687) from the LG/J and SM/J inbred mouse strains. The F2 provided strong support for several QTL, but within wide chromosomal regions. The AIL yielded much narrower QTL, but the… CONTINUE READING
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