• DOI:10.1182/BLOOD-2007-06-097386
• Corpus ID: 1518091

High-resolution donor-recipient HLA matching contributes to the success of unrelated donor marrow transplantation.

@article{Lee2007HighresolutionDH,
  title={High-resolution donor-recipient HLA matching contributes to the success of unrelated donor marrow transplantation.},
  author={Stephanie J. Lee and John P. Klein and Michael D. Haagenson and Lee Ann Baxter‐Lowe and Dennis L. Confer and Mary Eapen and Marcelo A. Fernandez-Vina and Neal Flomenberg and Mary M Horowitz and Carolyn Katovich Hurley and Harriet J. Noreen and Machteld Oudshoorn and Effie W. Petersdorf and Michelle I Setterholm and Stephen R. Spellman and Daniel J. Weisdorf and Thomas M. Williams and Claudio M. Anasetti},
  journal={Blood},
  year={2007},
  volume={110 13},
  pages={
          4576-83
        }
}

• Stephanie J. Lee, J. Klein, +15 authors C. Anasetti
• Published 15 December 2007
• Medicine
• Blood

The relative importance of various human leukocyte antigen (HLA) loci and the resolution level at which they are matched has not been fully defined for unrelated donor transplantation. To address this question, National Marrow Donor Program data from 3857 transplantations performed from 1988 to 2003 in the United States were analyzed. Patient-donor pairs were fully typed for HLA-A, -B, -C, -DRB1, -DQB1, -DQA1, -DPB1, and -DPA1 alleles. High-resolution DNA matching for HLA-A, -B, -C, and -DRB1 (8/8 match) was the minimum level of matching associated with the highest survival. A single mismatch detected by low- or high-resolution DNA testing at HLA-A, -B, -C or -DRB1 (7/8 match) was associated with higher mortality (relative risk, 1.25; 95% CI, 1.13-1.38; P < .001) and 1-year survival of 43% compared with 52% for 8/8 matched pairs. Single mismatches at HLA-B or HLA-C appear better tolerated than mismatches at HLA-A or HLA-DRB1. Mismatching at 2 or more loci compounded the risk. Mismatching at HLA-DP or -DQ loci and donor factors other than HLA type were not associated with survival. In multivariate modeling, patient age, race, disease stage, and cytomegalovirus status were as predictive of survival as donor HLA matching. High-resolution DNA matching for HLA-A, -B, -C, and -DRB1 alleles is associated with higher rates of survival.