High-resolution differential ion mobility separations using helium-rich gases.

  title={High-resolution differential ion mobility separations using helium-rich gases.},
  author={Alexandre A Shvartsburg and William F. Danielson and Richard D. Smith},
  journal={Analytical chemistry},
  volume={82 6},
Analyses of complex mixtures and characterization of ions increasingly involve gas-phase separations by ion mobility spectrometry (IMS) and particularly differential or field asymmetric waveform IMS (FAIMS) based on the difference of ion mobility in strong and weak electric fields. The key advantage of FAIMS is substantial orthogonality to mass spectrometry (MS), which makes FAIMS/MS hybrid a powerful analytical platform of broad utility. However, the potential of FAIMS has been constrained by… CONTINUE READING