High-resolution deletion mapping of 15q13.2-q21.1 in transitional cell carcinoma of the bladder.

@article{Natrajan2003HighresolutionDM,
  title={High-resolution deletion mapping of 15q13.2-q21.1 in transitional cell carcinoma of the bladder.},
  author={Rachael Natrajan and Jari Louhelainen and Sarah S Williams and Jonathan P. Laye and Margaret A Knowles},
  journal={Cancer research},
  year={2003},
  volume={63 22},
  pages={7657-62}
}
Deletions found in several types of human tumor, including carcinomas of the colorectum, breast, and lung, suggest the presence of a potential tumor suppressor gene(s) on chromosome 15. Common regions of deletion in these tumors are at 15q15 and 15q21. Here, we have analyzed loss of heterozygosity (LOH) on chromosome 15 to ascertain its potential involvement in the development and progression of transitional cell carcinoma (TCC) of the bladder. A panel of 26 polymorphic markers, spanning 15q12… CONTINUE READING
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