High-resolution crystal structure reveals molecular details of target recognition by bacitracin.

  title={High-resolution crystal structure reveals molecular details of target recognition by bacitracin.},
  author={Nicoleta J Economou and Simon Cocklin and Patrick J. Loll},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={110 35},
Bacitracin is a metalloantibiotic agent that is widely used as a medicine and feed additive. It interferes with bacterial cell-wall biosynthesis by binding undecaprenyl-pyrophosphate, a lipid carrier that serves as a critical intermediate in cell wall production. Despite bacitracin's broad use, the molecular details of its target recognition have not been elucidated. Here we report a crystal structure for the ternary complex of bacitracin A, zinc, and a geranyl-pyrophosphate ligand at a… CONTINUE READING
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