High-resolution crystal structure of the human Notch 1 ankyrin domain.

  title={High-resolution crystal structure of the human Notch 1 ankyrin domain.},
  author={Matthias T Ehebauer and Dimitri Y. Chirgadze and Penny Hayward and Alfonso Martinez Arias and Tom L. Blundell},
  journal={The Biochemical journal},
  volume={392 Pt 1},
The Notch receptor is part of a highly conserved signalling system of central importance to animal development. Its ANK (ankyrin) domain is required for Notch-mediated signal transduction. The crystal structure of the human Notch 1 ANK domain was solved by molecular replacement at 1.9 A (1 A=0.1 nm) resolution, and it shows that the features identified in the Drosophila homologue are conserved. The domain has six of the seven ANK repeats predicted from sequence. The putative first repeat, which… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.
24 Citations
51 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 24 extracted citations


Publications referenced by this paper.
Showing 1-10 of 51 references

Characterization of a high-molecular-weight complex in the nucleus of Notchic-transformed RKE cells and in a human T-cell leukaemia cell line

  • S. Jefferies, D. J. Robbins, A. J. Capobianco
  • Mol. Cell. Biol
  • 2002

Similar Papers

Loading similar papers…