High-resolution crystal structure of the eukaryotic HMP-P synthase (THIC) from Arabidopsis thaliana.

@article{Coquille2013HighresolutionCS,
  title={High-resolution crystal structure of the eukaryotic HMP-P synthase (THIC) from Arabidopsis thaliana.},
  author={Sandrine Coquille and C{\'e}line Roux and Angad P. Mehta and Tadhg P Begley and Teresa B Fitzpatrick and St{\'e}phane Thore},
  journal={Journal of structural biology},
  year={2013},
  volume={184 3},
  pages={
          438-44
        }
}
Vitamin B₁ is an essential compound in all organisms acting as a cofactor in key metabolic reactions. It is formed by the condensation of two independently biosynthesized molecules referred to as the pyrimidine and thiazole moieties. In bacteria and plants, the biosynthesis of the pyrimidine moiety, 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate (HMP… CONTINUE READING