High-resolution computed tomography scan and airway remodeling in children with severe asthma.

@article{Blic2005HighresolutionCT,
  title={High-resolution computed tomography scan and airway remodeling in children with severe asthma.},
  author={Jacques de Blic and Isabelle Tillie-Leblond and Sophie Emond and Bruno Mahut and Thanh Lan Dang Duy and Pierre Scheinmann},
  journal={The Journal of allergy and clinical immunology},
  year={2005},
  volume={116 4},
  pages={750-4}
}
BACKGROUND Children with severe asthma have a significantly higher bronchial wall thickness (BWT) on high-resolution computed tomography scan than control children. OBJECTIVE We sought to determine whether a BWT score correlates with markers of airway remodeling and inflammation. METHODS In 37 children with severe asthma, we determined reticular basement membrane thickness; number of intraepithelial neutrophils and eosinophils on bronchial biopsy; IFN-gamma, IL-4, IL-5, and eosinophil… CONTINUE READING
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