High-resolution comparative analysis of great ape genomes

@article{Kronenberg2018HighresolutionCA,
  title={High-resolution comparative analysis of great ape genomes},
  author={Zev N. Kronenberg and Ian T. Fiddes and David Gordon and Shwetha C. Murali and Stuart Cantsilieris and Olivia S Meyerson and Jason G. Underwood and Bradley J Nelson and Mark J. P. Chaisson and Max L Dougherty and Katherine M Munson and Alex R Hastie and Mark Diekhans and Fereydoun Hormozdiari and Nicola Lorusso and Kendra Hoekzema and Ruolan Qiu and Karen Clark and Archana Raja and AnneMarie E Welch and Melanie Sorensen and Carl T. Baker and Robert S. Fulton and Joel Armstrong and Tina A. Graves-Lindsay and Ahmet M Denli and Emma R Hoppe and Pinghsun Hsieh and Christopher M Hill and Andy Wing Chun Pang and Joyce Lee and Ernest T. Lam and Susan K. Dutcher and Fred H. Gage and Wesley C. Warren and Jay Shendure and David Haussler and Valerie A. Schneider and Han Cao and Mario Ventura and Richard K. Wilson and Benedict Paten and Alex A Pollen and Evan E. Eichler},
  journal={Science},
  year={2018},
  volume={360}
}
Genetic studies of human evolution require high-quality contiguous ape genome assemblies that are not guided by the human reference. We coupled long-read sequence assembly and full-length complementary DNA sequencing with a multiplatform scaffolding approach to produce ab initio chimpanzee and orangutan genome assemblies. By comparing these with two long-read de novo human genome assemblies and a gorilla genome assembly, we characterized lineage-specific and shared great ape genetic variation… CONTINUE READING

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