High resolution chromosome 3p allelotyping of human lung cancer and preneoplastic/preinvasive bronchial epithelium reveals multiple, discontinuous sites of 3p allele loss and three regions of frequent breakpoints.

@article{Wistuba2000HighRC,
  title={High resolution chromosome 3p allelotyping of human lung cancer and preneoplastic/preinvasive bronchial epithelium reveals multiple, discontinuous sites of 3p allele loss and three regions of frequent breakpoints.},
  author={I I Wistuba and C Behrens and A K Virmani and G Mele and S Milchgrub and L Girard and John W. Fondon and H R Garner and B McKay and F Latif and M. I. Lerman and S Lam and A F Gazdar and John D. Minna},
  journal={Cancer research},
  year={2000},
  volume={60 7},
  pages={1949-60}
}
  • I I Wistuba, C Behrens, +11 authors John D. Minna
  • Published 2000 in Cancer research
Allele loss involving chromosome arm 3p is one of the most frequent and earliest known genetic events in lung cancer pathogenesis and may affect several potential tumor suppressor gene regions. To further study the role of chromosome 3p allele loss in the pathogenesis of lung cancer, we performed high resolution loss of heterozygosity (LOH) studies on 97 lung cancer and 54 preneoplastic/preinvasive microdissected respiratory epithelial samples using a panel of 28 3p markers. Allelic losses of… CONTINUE READING
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Referenced Papers

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Showing 1-10 of 74 references

Molecular biology of lung

  • J. D. Minna, Y. Sekido, K. Fong, A. F. Gazdar
  • Cancer: Principles and Practice of Oncology,
  • 1997
Highly Influential
11 Excerpts

Tumors of the Lower Respiratory Tract

  • T. V. Colby, M. N. Koss, W. D. Travis
  • 3rd series,
  • 1995
Highly Influential
12 Excerpts

Cancer statistics ,

  • P. A. Wingo
  • CA Cancer J . Clin .
  • 1999

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